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UK Drugs in Lactation Advisory Service

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Vitamins

Drugs
Suitability for use in lactation
Comments

* There are additional nutritional requirements during lactation for vitamin A, riboflavin, niacin, vitamin B12, folate, vitamin C and vitamin D. Vitamin tablets for nursing mothers are available. A well-balanced diet should be encouraged.
* Use of megadose vitamin regimens should be avoided

Vitamin A Vitamin A (low dose - values up to UK reference nutrient intake - 950 mcg retinol equivalents/day in lactating women Yes If amount does not exceed the daily reference nutrient intake value
  Vitamin A (high dose, therapeutic use) No Increased milk content.Risk of hypervitaminosis
Vitamin B Group B1 - Thiamine
Yes Supplements do not affect milk levels above a ceiling level
  B2 - Riboflavine Yes Supplements have little effect on milk levels in well nourished mothers
  B6 – Pyridoxine(low dose - values up to reference nutrient intake - 15mcg/g protein daily) Yes Supplements improve milk content
  B12 -Cyanocobalamin Yes Supplements improve milk content
  Folate Yes Increased dietary requirement in lactation. Milk folate maintained at expense of maternal reserves
Vitamin C Vitamin C Yes Supplements have minimal effect on milk concentration
Vitamin D Vitamin D (low dose values up to reference nutrient intake - 10mcg/day in lactating women) Yes Supplements improve milk content
  Vitamin D (high dose, therapeutic use) No Increased milk content.Risk of hypervitaminosis
Vitamin E Vitamin E ? Effect of supplements on milk content unknown; Low dose supplements unlikely to cause adverse effects
Vitamin K Vitamin K Yes Supplements have minimal effect on milk levels. Additional neonatal supplements required to prevent haemorrhagic disease of the newborn

Drugs classified with '?' should be used with caution and only after an assessment of benefit to the mother versus risk, real or potential, to the infant. These drugs either have insufficient clinical data on their use in lactation to regard as absolutely safe or they have had minor, reversible side effects reported in a breast-fed infant.